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Andres L. Lozano, M.D., Ph.D.
FRCS(C)
Site Principal Investigator, University of
Toronto
Dr. Lozano is Professor in
the Department of Surgery/Division of Neurosurgery at the University of
Toronto in Canada, where he holds the Ron Tasker Chair in Stereotactic
and Functional Neurosurgery, as well as a Tier 1 Canada Research Chair
in Neuroscience. He is head of Applied and Interventional Research at
Toronto Western Hospital and Senior Scientist at the Division of Brain
Imaging & Behavior Systems at the Toronto Western Research Institute.
At the University of Ottawa
he obtained his degrees in cell biology, biochemistry and medicine, and
at McGill University his Ph.D. degree. He has been active in many
associations, and in 2005, was elected president of the World Society
for Stereotactic and Functional Neurosurgery.
His main research and
clinical interests lie in the field of the neurosurgical treatment of
movement disorders and microelectrode recordings of the human brain.
Using models of Parkinson’s disease his research aims at uncovering the
mechanisms through which dopamine neurons die and developing novel
strategies to prevent this from happening.
A second
focus is functional neurosurgery, which involves interventions designed
to enhance or reestablish disrupted neurological function. In deep brain
stimulation therapy, tiny electrodes are implanted at precise locations
and powered by an internal pulse generator to provide stimulation as
needed to restore function. Such therapy is used for patients with
Parkinson’s disease, dystonia, epilepsy and pain, and Dr. Lozano is
pioneering therapy involving the cingulum and Brodmann area 25 in
patients with depression. These approaches also help in advancing the
understanding of the pathogenesis of these disorders.
Selected
Publications
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